In his Frankenstein research lab, Rene Descartes nailed dogs' paws to tables, a modern crucifixion, impaling them that they not be able to escape the imposition of agony.
He believed animals did not have thought capability and that they had no feelings, though they screamed when he inflicted pain on them.
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Of course you know that Descartes was famous for saying: I think, therefore I am. Well, did you ever hear how Descartes met his end? A friend of his came up to him one day and asked, Say, Old Chap, do you think I'm good looking? Descartes replied: I think not. and POOF! he disappeared just like that!